Yohimbe might not be safe (especially at yohimbine doses of 20 mg or higher). Use it only with guidance from your health care provider because the side effects can be severe.
Other research has found that vitamin D supplementation may help regulate mood and ease depression, especially if you are deficient.
Side effects will depend on the active ingredients in the supplement you choose. Read labels carefully and discuss any concerns with a pharmacist or another healthcare professional.
Figuring out whether these ingredients really help you lose weight safely is complicated, though. Most products contain more than one ingredient, and ingredients can work differently when they’re mixed together.
Still, maintaining weight loss is notoriously challenging. In fact, a study in BioPsychoSocial Medicine found that nearly 70 percent of people were unsuccessful in maintaining a 10 percent weight loss for two years. This might make it seem like the odds are stacked against you, but actually, weight maintenance can be successful with a change in focus from weight loss habits.
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Calcium—either from food or in weight-loss dietary supplements—probably doesn't help you lose weight or prevent weight gain.
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Limited human research has been conducted on the potential for dietary supplementation to affect disease risk. Examples:
Fucoxanthin comes from brown seaweed and other algae. It's claimed to help with weight loss by burning calories and decreasing fat.
Being active is vital to losing weight and keeping if off. An active body uses energy, measured in calories, to move. This helps burn the calories you take in from food you eat. And sitting too much isn't good for you.
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Exercise has many other benefits. It can lift your mood, lower blood pressure and help you sleep better. Exercise helps you keep off the weight that you lose too. Studies show that people who maintain their weight loss over the long term get regular physical activity.
To assure supplements have sufficient quality, standardization, and safety for public consumption, research efforts have focused on development of reference materials for supplement manufacturing and monitoring.